Research in Dr. Mishra's laboratory focuses on the relationship between genetic, biochemical, and molecular mechanisms and neuropsychiatric disorders such as schizophrenia and Parkinson's disease. The research team is particularly interested in the role of dopamine receptors in various disease processes, where understanding the molecular basis of their dysfunction could contribute to potential improvements in either disease detection or treatment. The laboratory has been uninterruptedly funded from CIHR, NSERC, and OMHF for the last several years and currently receives major funding from these agencies.
The following projects are currently active in the lab:
a) Role of synapsin II in the pathophysiology of schizophrenia: Recent efforts have led to the discovery of novel mechanisms suggesting that synapsin II may be one of the underlying causal factors in the pathophysiology of schizophrenia.
b) Development of allosteric drugs targeting dopamine D2L receptors: Recent work has led to the discovery of novel compounds that may be useful for the treatment of negative, positive, and cognitive symptoms of schizophrenia.
c) Role of apoptosis-inducing factor (AIF) in typical antipsychotic drug-induced cell death: Recent work led to the discovery of caspase-independent mechanisms for cell death induced by haloperiodol treatment in humans.
d) Role of conserved dopamine neurotrophic factor (CDNF) and cyclin-dependent kinase 5 (Cdk5) in neurodevelopment.